This new edition of the benchmark text on clinical pediatric endocrinology still remains at the forefront of world clinical opinion. Furthermore, the style, which has been the hallmark of the book for the last 20 years, has been maintained for this fifth edition. Special new chapters cover the fetal origins of adult disease and the endocrine consequences and management of critical illness. This fifth edition now opens with a basic science section summarizing the mechanisms of hormone action, genomics, proteomics and the application of molecular biology to clinical practice. Two new co-editors have been introduced – Peter Clayton and Rosalind Brown and every chapter has been updated.